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Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase
The X-ray crystal structures of human purine nucleoside phosphorylase (PNP) with bound inosine or transition state analogues show His(257) within hydrogen-bonding distance to the 5′-hydroxyl. The mutants His257Phe, His257Gly, and His257Asp exhibited greatly decreased affinity for Immucillin-H (ImmH)...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2526054/ https://ncbi.nlm.nih.gov/pubmed/17407325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700147b |
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