Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase

Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of 6-oxy-purine nucleosides to the corresponding purine base and α-d-ribose 1-phosphate. Its genetic loss causes a lethal T-cell deficiency. The highly reactive ribocation transition state of human PNP is protected from solvent by hy...

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Hlavní autoři: Ghanem, Mahmoud, Murkin, Andrew S., Schramm, Vern L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752651/
https://ncbi.nlm.nih.gov/pubmed/19778725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.012
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