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Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase
Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of 6-oxy-purine nucleosides to the corresponding purine base and α-d-ribose 1-phosphate. Its genetic loss causes a lethal T-cell deficiency. The highly reactive ribocation transition state of human PNP is protected from solvent by hy...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752651/ https://ncbi.nlm.nih.gov/pubmed/19778725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.012 |
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