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Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase
Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of 6-oxypurine (2′-deoxy)ribonucleosides, generating (2-deoxy)ribose 1-phosphate and the purine base. Transition-state models for inosine cleavage have been proposed with bovine, human, and malarial PNPs using arsenate as...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070384/ https://ncbi.nlm.nih.gov/pubmed/21348499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200279s |
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