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The synthesis of 2,5-Bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease
Botulinum neurotoxins (BoNTs), composed of a family of seven serotypes (categorized A – G), are the deadliest of known biological toxins. The activity of the metalloprotease, light chain (LC) component of the toxins is responsible for causing the life-threatening paralysis associated with the diseas...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361628/ https://ncbi.nlm.nih.gov/pubmed/22516424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.03.043 |
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