The synthesis of 2,5-Bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease

Botulinum neurotoxins (BoNTs), composed of a family of seven serotypes (categorized A – G), are the deadliest of known biological toxins. The activity of the metalloprotease, light chain (LC) component of the toxins is responsible for causing the life-threatening paralysis associated with the diseas...

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Hlavní autoři: Opsenica, Igor, Filipovic, Vuk, Nuss, Jon E., Gomba, Laura M., Opsenica, Dejan, Burnett, James C., Gussio, Rick, Solaja, Bogdan A., Bavari, Sina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361628/
https://ncbi.nlm.nih.gov/pubmed/22516424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.03.043
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