Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were synthesized and their DNA binding, fluorescence properties, in vitro and in vivo activities were evaluated. These compounds are shown to bind in the DNA minor groove w...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Farahat, Abdelbasset A., Kumar, Arvind, Say, Martial, Wenzler, Tanja, Brun, Reto, Paul, Ananya, Wilson, W. David, Boykin, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Editions Scientifiques Elsevier 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341734/
https://ncbi.nlm.nih.gov/pubmed/28152428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.01.037
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