Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

The DAPI structure has been modified by replacing the phenyl group with substituted phenyl or heteroaryl rings. Twelve amidines were synthesized and their DNA binding, fluorescence properties, in vitro and in vivo activities were evaluated. These compounds are shown to bind in the DNA minor groove w...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Farahat, Abdelbasset A., Kumar, Arvind, Say, Martial, Wenzler, Tanja, Brun, Reto, Paul, Ananya, Wilson, W. David, Boykin, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341734/
https://ncbi.nlm.nih.gov/pubmed/28152428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.01.037
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