Synthesis and Antiprotozoal Activity of Dicationic 2, 6-Diphenylpyrazines and Aza-Analogues

Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) in vitro, efficacy in T. b. r. STIB900 acute and T. b. brucei GVR35 CNS mouse models. Most diamidine...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hu, Laixing, Patel, Alpa, Bondada, Lavanya, Yang, Sihyung, Wang, Michael Zhuo, Munde, Manoj, Wilson, W. David, Wenzler, Tanja, Brun, Reto, Boykin, David W.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846175/
https://ncbi.nlm.nih.gov/pubmed/24012380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.08.006
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