Synthesis and Antiprotozoal Activity of Dicationic 2, 6-Diphenylpyrazines and Aza-Analogues

Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) in vitro, efficacy in T. b. r. STIB900 acute and T. b. brucei GVR35 CNS mouse models. Most diamidine...

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Autori principali: Hu, Laixing, Patel, Alpa, Bondada, Lavanya, Yang, Sihyung, Wang, Michael Zhuo, Munde, Manoj, Wilson, W. David, Wenzler, Tanja, Brun, Reto, Boykin, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846175/
https://ncbi.nlm.nih.gov/pubmed/24012380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.08.006
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