Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum

A series of azaterphenyl diamidines has been synthesized and evaluated for in vitro antiprotozoal activity against both Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) and in vivo efficacy in the STIB900 acute mouse model for T. b. r. Six of the 13 compounds showed IC(50)...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Hu, Laixing, Arafa, Reem K., Ismail, Mohamed A., Patel, Alpa, Munde, Manoj, Wilson, W. David, Wenzler, Tanja, Brun, Reto, Boykin, David W.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813006/
https://ncbi.nlm.nih.gov/pubmed/19699098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.07.080
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki