Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum

A series of azaterphenyl diamidines has been synthesized and evaluated for in vitro antiprotozoal activity against both Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) and in vivo efficacy in the STIB900 acute mouse model for T. b. r. Six of the 13 compounds showed IC(50)...

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Autors principals: Hu, Laixing, Arafa, Reem K., Ismail, Mohamed A., Patel, Alpa, Munde, Manoj, Wilson, W. David, Wenzler, Tanja, Brun, Reto, Boykin, David W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813006/
https://ncbi.nlm.nih.gov/pubmed/19699098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.07.080
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