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Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents
A series of triaryl guanidines and N-substituted guanidines designed to target the minor groove of DNA were synthesized and evaluated as antiprotozoal agents. Selected carbamate prodrugs of these guanidines were assayed for their oral efficacy. The linear triaryl bis-guanidines 6a,b were prepared fr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3815585/ https://ncbi.nlm.nih.gov/pubmed/18455271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2008.02.008 |
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