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Synthesis and Antiprotozoal Activity of 2,5-Bis[amidinoaryl]thiazoles
Seven novel diamidino 2,5-bis(aryl)thiazoles (5a–5g) were synthesized and evaluated against Trypanosoma brucei rhodensiense (T. b. r.) and Plasmodium falciparum (P. f). The diamidines were obtained directly from the corresponding bis-nitriles (4a–g) by the action of lithium bis(trimethylsilyl)amide....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892117/ https://ncbi.nlm.nih.gov/pubmed/20403703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.03.058 |
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