Synthesis and Antiprotozoal Activity of 2,5-Bis[amidinoaryl]thiazoles

Seven novel diamidino 2,5-bis(aryl)thiazoles (5a–5g) were synthesized and evaluated against Trypanosoma brucei rhodensiense (T. b. r.) and Plasmodium falciparum (P. f). The diamidines were obtained directly from the corresponding bis-nitriles (4a–g) by the action of lithium bis(trimethylsilyl)amide....

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Hauptverfasser: Branowska, Danuta, Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Liu, Yang, Wilson, W. David, Boykin, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892117/
https://ncbi.nlm.nih.gov/pubmed/20403703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.03.058
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