Pharmacokinetics, Trypanosoma brucei gambiense Efficacy, and Time of Drug Action of DB829, a Preclinical Candidate for Treatment of Second-Stage Human African Trypanosomiasis

Human African trypanosomiasis (HAT, also called sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei gambiense and T. brucei rhodesiense. Current drugs against this disease have significant limitations, including toxicity, incr...

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Autores principales: Wenzler, Tanja, Yang, Sihyung, Braissant, Olivier, Boykin, David W., Brun, Reto, Wang, Michael Zhuo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811327/
https://ncbi.nlm.nih.gov/pubmed/23959303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00398-13
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