Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Tryp...

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Bibliografische gegevens
Hoofdauteurs: Graf, Fabrice E., Ludin, Philipp, Wenzler, Tanja, Kaiser, Marcel, Brun, Reto, Pyana, Patient Pati, Büscher, Philippe, de Koning, Harry P., Horn, David, Mäser, Pascal
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794916/
https://ncbi.nlm.nih.gov/pubmed/24130910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002475
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