Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant Trypanosoma brucei gambiense isolates from sleeping...

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Detalles Bibliográficos
Publicado en:Int J Parasitol Drugs Drug Resist
Main Authors: Graf, Fabrice E., Baker, Nicola, Munday, Jane C., de Koning, Harry P., Horn, David, Mäser, Pascal
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
Assuntos:
Brief Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443405/
https://ncbi.nlm.nih.gov/pubmed/26042196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2015.04.002
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