Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction

Por LeClair, Christopher A., Boxer, Matthew B., Thomas, Craig J., Maloney, David J.
Publicado em 2010

A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety

Por Boxer, Matthew B., Quinn, Amy M., Shen, Min, Jadhav, Ajit, Leister, William, Simeonov, Anton, Auld, Douglas S., Thomas, Craig J.
Publicado em 2010

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors

Por Thomas, Ajit G., Rojas, Camilo, Tanega, Cordelle, Shen, Min, Simeonov, Anton, Boxer, Matthew B., Auld, Douglas S., Ferraris, Dana V., Tsukamoto, Takashi, Slusher, Barbara S.
Publicado em 2013

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors

Por Duveau, Damien Y., Hu, Xin, Walsh, Martin J., Shukla, Suneet, Skoumbourdis, Amanda P., Boxer, Matthew B., Ambudkar, Suresh V., Shen, Min, Thomas, Craig J.
Publicado em 2012

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Por Merk, Alan, Bartesaghi, Alberto, Banerjee, Soojay, Falconieri, Veronica, Rao, Prashant, Davis, Mindy, Pragani, Rajan, Boxer, Matthew, Earl, Lesley A., Milne, Jacqueline L.S., Subramaniam, Sriram
Publicado no Cell (2016)

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose

Por Tee, Sui Seng, Park, Jae Mo, Hurd, Ralph E., Brimacombe, Kyle R., Boxer, Matthew B., Massoud, Tarik F., Rutt, Brian K., Spielman, Daniel M.
Publicado no Oncotarget (2017)

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna(®)) with the human ABC drug transporter P-glycoprotein

Por Shukla, Suneet, Chufan, Eduardo E., Singh, Satyakam, Skoumbourdis, Amanda P., Kapoor, Khyati, Boxer, Matthew B., Duveau, Damien Y., Thomas, Craig J., Talele, Tanaji T., Ambudkar, Suresh V.
Publicado em 2014

CS-33 DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME

Por Sumita, Kazutaka, Davis, Mindy, Pragani, Rajan, Terakawa, Jumpei, Daikoku, Takiko, Majd, Nazanin, Shen, Min, Li, Zhuyin, Hu, Xin, Cantley, Lewis, Boxer, Matthew, Simeonov, Anton, Sasaki, Atsuo
Publicado em 2014

Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity towards multidrug-resistant cells expressing P-glycoprotein()

Por Hall, Matthew D., Brimacombe, Kyle R., Varonka, Matthew S., Pluchino, Kristen M., Monda, Julie K., Li, Jiayang, Walsh, Martin J., Boxer, Matthew B., Warren, Timothy H., Fales, Henry M., Gottesman, Michael M.
Publicado em 2011

A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation

Por Davis, Mindy I., Sasaki, Atsuo T., Shen, Min, Emerling, Brooke M., Thorne, Natasha, Michael, Sam, Pragani, Rajan, Boxer, Matthew, Sumita, Kazutaka, Takeuchi, Koh, Auld, Douglas S., Li, Zhuyin, Cantley, Lewis C., Simeonov, Anton
Publicado em 2013

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

Por Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Bellinger, Gary, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Vander Heiden, Matthew G., Cantley, Lewis C.
Publicado em 2011

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Por Zhang, Lisa, Zhang, Yaqin, Mehta, Amit, Boufraqech, Myriem, Davis, Sean, Wang, Jing, Tian, Ze, Yu, Zhiya, Boxer, Matthew B., Kiefer, Jeffrey A., Copland, John A., Smallridge, Robert C., Li, Zhuyin, Shen, Min, Kebebew, Electron
Publicado no Oncotarget (2015)

2-oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Por Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Israelsen, William J., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B.
Publicado em 2011

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase

Por Morgan, Hugh P., Walsh, Martin J., Blackburn, Elizabeth A., Wear, Martin A., Boxer, Matthew B., Shen, Min, Mcnae, Iain W., Nowicki, Matthew W., Michels, Paul A. M., Auld, Douglas S., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado em 2012

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

Por Davis, Mindy I., Gross, Stefan, Shen, Min, Straley, Kimberly S., Pragani, Rajan, Lea, Wendy A., Popovici-Muller, Janeta, DeLaBarre, Byron, Artin, Erin, Thorne, Natasha, Auld, Douglas S., Li, Zhuyin, Dang, Lenny, Boxer, Matthew B., Simeonov, Anton
Publicado em 2014

Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Por Boxer, Matthew B., Jiang, Jian-kang, Vander Heiden, Matthew G., Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Veith, Henrike, Leister, William, Austin, Christopher P., Park, Hee Won, Inglese, James, Cantley, Lewis C., Auld, Douglas S., Thomas, Craig J.
Publicado em 2010

Evaluation of Thieno[3,2-b]pyrrole[3,2-d]pyridazinones as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Por Jiang, Jian-kang, Boxer, Matthew B., Vander Heiden, Matthew G., Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Veith, Henrike, Leister, William, Austin, Christopher P., Park, Hee Won, Inglese, James, Cantley, Lewis C., Auld, Douglas S., Thomas, Craig J.
Publicado em 2010

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Por Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst
Publicado no Nat Commun (2015)

Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Por Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst
Publicado no Nat Commun (2016)

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

Por Brimacombe, Kyle R., Walsh, Martin J., Liu, Li, Vásquez-Valdivieso, Montserrat G., Morgan, Hugh P., McNae, Iain, Fothergill-Gilmore, Linda A., Michels, Paul A. M., Auld, Douglas S., Simeonov, Anton, Walkinshaw, Malcolm D., Shen, Min, Boxer, Matthew B.
Publicado em 2013