Evaluation of Thieno[3,2-b]pyrrole[3,2-d]pyridazinones as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Cancer cells have distinct metabolic needs that are different from normal cells and can be exploited for development of anti-cancer therapeutics. Activation of the tumor specific M2 form of pyruvate kinase (PKM2) is a potential strategy for returning cancer cells to a metabolic state characteristic...

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Main Authors: Jiang, Jian-kang, Boxer, Matthew B., Vander Heiden, Matthew G., Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Veith, Henrike, Leister, William, Austin, Christopher P., Park, Hee Won, Inglese, James, Cantley, Lewis C., Auld, Douglas S., Thomas, Craig J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874658/
https://ncbi.nlm.nih.gov/pubmed/20451379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.04.015
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