Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

The metabolism of cancer cells is altered to support rapid proliferation. Pharmacological activators of a tumor cell specific pyruvate kinase isozyme (PKM2) may be an approach for altering the classic Warburg effect characteristic of aberrant metabolism in cancer cells yielding a novel anti-prolifer...

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Main Authors: Boxer, Matthew B., Jiang, Jian-kang, Vander Heiden, Matthew G., Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Veith, Henrike, Leister, William, Austin, Christopher P., Park, Hee Won, Inglese, James, Cantley, Lewis C., Auld, Douglas S., Thomas, Craig J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818804/
https://ncbi.nlm.nih.gov/pubmed/20017496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901577g
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