Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. PKM2 interaction with phosphotyrosine-containing proteins inhibits enzyme activity and increases a...

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Detalhes bibliográficos
Main Authors: Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J., Jiang, Jian-kang, Boxer, Matthew B., Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R., Metallo, Christian M., Fiske, Brian P., Courtney, Kevin D., Malstrom, Scott, Khan, Tahsin M., Kung, Charles, Skoumbourdis, Amanda P., Veith, Henrike, Southall, Noel, Walsh, Martin J., Brimacombe, Kyle R., Leister, William, Lunt, Sophia Y., Johnson, Zachary R., Yen, Katharine E., Kunii, Kaiko, Davidson, Shawn M., Christofk, Heather R., Austin, Christopher P., Inglese, James, Harris, Marian H., Asara, John M., Stephanopoulos, Gregory, Salituro, Francesco G., Jin, Shengfang, Dang, Lenny, Auld, Douglas S., Park, Hee-Won, Cantley, Lewis C., Thomas, Craig J., Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711671/
https://ncbi.nlm.nih.gov/pubmed/22922757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1060
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