2-oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform is a highly active enzyme, the alternatively splice...

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Hauptverfasser: Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Israelsen, William J., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224553/
https://ncbi.nlm.nih.gov/pubmed/21958545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.08.114
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