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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

Cancer cells preferentially metabolize glucose by aerobic glycolysis, characterized by increased lactate production. This distinctive metabolism involves expression of the embryonic M2 isozyme of pyruvate kinase, in contrast to the M1 isozyme normally expressed in differentiated cells, and it confer...

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Detalhes bibliográficos
Main Authors: Clower, Cynthia V., Chatterjee, Deblina, Wang, Zhenxun, Cantley, Lewis C., Vander Heiden, Matthew G., Krainer, Adrian R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838216/
https://ncbi.nlm.nih.gov/pubmed/20133837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914845107
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