The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

Cancer cells preferentially metabolize glucose by aerobic glycolysis, characterized by increased lactate production. This distinctive metabolism involves expression of the embryonic M2 isozyme of pyruvate kinase, in contrast to the M1 isozyme normally expressed in differentiated cells, and it confer...

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Autors principals: Clower, Cynthia V., Chatterjee, Deblina, Wang, Zhenxun, Cantley, Lewis C., Vander Heiden, Matthew G., Krainer, Adrian R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838216/
https://ncbi.nlm.nih.gov/pubmed/20133837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914845107
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