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Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons
Alternative splicing of the pyruvate kinase M gene (PK-M) can generate the M2 isoform and promote aerobic glycolysis and tumor growth. However, the cancer-specific alternative splicing regulation of PK-M is not completely understood. Here, we demonstrate that PK-M is regulated by reciprocal effects...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493165/ https://ncbi.nlm.nih.gov/pubmed/22044881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjr030 |
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