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Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate...

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Main Authors: Wang, Zhenxun, Jeon, Hyun Yong, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Royal Society 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498831/
https://ncbi.nlm.nih.gov/pubmed/23155487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120133
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