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Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate...

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Bibliografische gegevens
Hoofdauteurs: Wang, Zhenxun, Jeon, Hyun Yong, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Royal Society 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498831/
https://ncbi.nlm.nih.gov/pubmed/23155487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120133
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