Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate...

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Bibliografske podrobnosti
Main Authors: Wang, Zhenxun, Jeon, Hyun Yong, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498831/
https://ncbi.nlm.nih.gov/pubmed/23155487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120133
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