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Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
BACKGROUND: Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: the full-length APOB100 isoform, assembled into LDL, VLDL, IDL and Lp(a) and...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BioMed Central
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1784105/ https://ncbi.nlm.nih.gov/pubmed/17233885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-8-3 |
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