HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA

CHRNA1 gene, encoding the muscle nicotinic acetylcholine receptor alpha subunit, harbors an inframe exon P3A. Inclusion of exon P3A disables assembly of the acetylcholine receptor subunits. A single nucleotide mutation in exon P3A identified in congenital myasthenic syndrome causes exclusive inclusi...

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Detalhes bibliográficos
Main Authors: Rahman, Mohammad Alinoor, Masuda, Akio, Ohe, Kenji, Ito, Mikako, Hutchinson, David O., Mayeda, Akila, Engel, Andrew G., Ohno, Kinji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796306/
https://ncbi.nlm.nih.gov/pubmed/24121633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02931
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