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Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors
Glutaminase catalyzes the hydrolysis of glutamine to glutamate and plays a central role in the proliferation of neoplastic cells via glutaminolysis, as well as in the generation of excitotoxic glutamate in central nervous system disorders such as HIV-associated dementia (HAD) and multiple sclerosis....
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094369/ https://ncbi.nlm.nih.gov/pubmed/23850693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.06.110 |
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