Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors

Glutaminase catalyzes the hydrolysis of glutamine to glutamate and plays a central role in the proliferation of neoplastic cells via glutaminolysis, as well as in the generation of excitotoxic glutamate in central nervous system disorders such as HIV-associated dementia (HAD) and multiple sclerosis....

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Main Authors: Thomas, Ajit G., Rojas, Camilo, Tanega, Cordelle, Shen, Min, Simeonov, Anton, Boxer, Matthew B., Auld, Douglas S., Ferraris, Dana V., Tsukamoto, Takashi, Slusher, Barbara S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094369/
https://ncbi.nlm.nih.gov/pubmed/23850693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.06.110
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