Small Molecule Glutaminase Inhibitors Block Glutamate Release from Stimulated Microglia

Glutaminase plays a critical role in the generation of glutamate, a key excitatory neurotransmitter in the CNS. Excess glutamate release from activated macrophages and microglia correlates with upregulated glutaminase suggesting a pathogenic role for glutaminase. Both glutaminase siRNA and small mol...

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Detalles Bibliográficos
Autores principales: Thomas, Ajit G., O'Driscoll, Cliona M., Bressler, Joseph, Kaufmann, Walter E., Rojas, Camilo J., Slusher, Barbara S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927782/
https://ncbi.nlm.nih.gov/pubmed/24269238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.11.043
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