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Small Molecule Glutaminase Inhibitors Block Glutamate Release from Stimulated Microglia
Glutaminase plays a critical role in the generation of glutamate, a key excitatory neurotransmitter in the CNS. Excess glutamate release from activated macrophages and microglia correlates with upregulated glutaminase suggesting a pathogenic role for glutaminase. Both glutaminase siRNA and small mol...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927782/ https://ncbi.nlm.nih.gov/pubmed/24269238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.11.043 |
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