High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells

The cystine-glutamate antiporter (system x(c) (-)) is a Na(+)-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intracellular glutathione synthesis via cystine u...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Thomas, Ajit G., Sattler, Rita, Tendyke, Karen, Loiacono, Kara A., Hansen, Hans, Sahni, Vishal, Hashizume, Yutaka, Rojas, Camilo, Slusher, Barbara S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529246/
https://ncbi.nlm.nih.gov/pubmed/26252954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127785
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