Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

The targeting of glutamine metabolism specifically via pharmacological inhibition of glutaminase 1 (GLS1) has been translated into clinical trials as a novel therapy for several cancers. The results, though encouraging, show room for improvement in terms of tumor reduction. In this study, the glutam...

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Udgivet i:Proteomics
Main Authors: Udupa, Sunag, Nguyen, Stephanie, Hoang, Giang, Nguyen, Tu, Quinones, Addison, Pham, Khoa, Asaka, Ryoichi, Nguyen, Kiet, Zhang, Cissy, Elgogary, Amira, Jung, Jin G., Xu, Qingguo, Fu, Jie, Thomas, Ajit G., Tsukamoto, Takashi, Hanes, Justin, Slusher, Barbara S., Cooper, Arthur J. L., Le, Anne
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Accelerated Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851409/
https://ncbi.nlm.nih.gov/pubmed/31231915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201800451
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