Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Background: Elevated glutamate production and release from glial cells is a common feature of many CNS disorders. Inhibitors of glutaminase (GLS), the enzyme responsible for converting glutamine to glutamate have been developed to target glutamate overproduction. However, many GLS inhibitors have po...

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Dades bibliogràfiques
Publicat a:Theranostics
Autors principals: Khoury, Elizabeth Smith, Sharma, Anjali, Ramireddy, Rajasekhar R, Thomas, Ajit G., Alt, Jesse, Fowler, Amanda, Rais, Rana, Tsukamoto, Takashi, Blue, Mary E., Slusher, Barbara, Kannan, Sujatha, Kannan, Rangaramanujam M.
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254984/
https://ncbi.nlm.nih.gov/pubmed/32483415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.41714
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