Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Background: Elevated glutamate production and release from glial cells is a common feature of many CNS disorders. Inhibitors of glutaminase (GLS), the enzyme responsible for converting glutamine to glutamate have been developed to target glutamate overproduction. However, many GLS inhibitors have po...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Theranostics
Glavni autori: Khoury, Elizabeth Smith, Sharma, Anjali, Ramireddy, Rajasekhar R, Thomas, Ajit G., Alt, Jesse, Fowler, Amanda, Rais, Rana, Tsukamoto, Takashi, Blue, Mary E., Slusher, Barbara, Kannan, Sujatha, Kannan, Rangaramanujam M.
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2020
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254984/
https://ncbi.nlm.nih.gov/pubmed/32483415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.41714
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items