Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Background: Elevated glutamate production and release from glial cells is a common feature of many CNS disorders. Inhibitors of glutaminase (GLS), the enzyme responsible for converting glutamine to glutamate have been developed to target glutamate overproduction. However, many GLS inhibitors have po...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Khoury, Elizabeth Smith, Sharma, Anjali, Ramireddy, Rajasekhar R, Thomas, Ajit G., Alt, Jesse, Fowler, Amanda, Rais, Rana, Tsukamoto, Takashi, Blue, Mary E., Slusher, Barbara, Kannan, Sujatha, Kannan, Rangaramanujam M.
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2020
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Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254984/
https://ncbi.nlm.nih.gov/pubmed/32483415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.41714
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