Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

N-acetyl-aspartyl-glutamate (NAAG) is a peptide-based neurotransmitter that has been extensively studied in many neurological diseases. In this study, we show a specific role of NAAG in cancer. We found that NAAG is more abundant in higher grade cancers and is a source of glutamate in cancers expres...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Nguyen, Tu, Kirsch, Brian James, Asaka, Ryoichi, Nabi, Karim, Quinones, Addison, Tan, Jessica, Antonio, Marjorie Justine, Camelo, Felipe, Li, Ting, Nguyen, Stephanie, Hoang, Giang, Nguyen, Kiet, Udupa, Sunag, Sazeides, Christos, Shen, Yao-An, Elgogary, Amira, Reyes, Juvenal, Zhao, Liang, Kleensang, Andre, Chaichana, Kaisorn Lee, Hartung, Thomas, Betenbaugh, Michael J., Marie, Suely K., Jung, Jin G., Wang, Tian-Li, Gabrielson, Edward, Le, Anne
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472703/
https://ncbi.nlm.nih.gov/pubmed/30970252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.036
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