Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity towards multidrug-resistant cells expressing P-glycoprotein()

Cancer multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters presents a significant unresolved clinical challenge. One strategy to resolve MDR is to develop compounds that selectively kill cells over-expressing the efflux transporter P-glycoprotein (MDR1, P-gp, ABCB1). We ha...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hall, Matthew D., Brimacombe, Kyle R., Varonka, Matthew S., Pluchino, Kristen M., Monda, Julie K., Li, Jiayang, Walsh, Martin J., Boxer, Matthew B., Warren, Timothy H., Fales, Henry M., Gottesman, Michael M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201829/
https://ncbi.nlm.nih.gov/pubmed/21721528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2006047
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak