Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin

A major challenge in the treatment of cancer is multidrug resistance (MDR) that develops during chemotherapy. Here we demonstrate that tiopronin (1), a thiol-substituted N-propanoylglycine derivative, was selectively toxic to a series of cell lines expressing the drug efflux pump P-glycoprotein (P-g...

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Huvudupphovsmän: Goldsborough, Andrew S., Handley, Misty D., Dulcey, Andrés E., Pluchino, Kristen M., Kannan, Pavitra, Brimacombe, Kyle R., Hall, Matthew D., Griffiths, Gary, Gottesman, Michael M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208667/
https://ncbi.nlm.nih.gov/pubmed/21657271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2001663
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