Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-resistant Cells to Tiopronin

Multidrug resistance (MDR) is a major obstacle to the successful chemotherapy of cancer. MDR is often the result of overexpression of ATP-binding cassette transporters following chemotherapy. A common ATP-binding cassette transporter that is overexpressed in MDR cancer cells is P-glycoprotein, which...

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Main Authors: Hall, Matthew D., Marshall, Travis S., Kwit, Alexandra D. T., Miller Jenkins, Lisa M., Dulcey, Andrés E., Madigan, James P., Pluchino, Kristen M., Goldsborough, Andrew S., Brimacombe, Kyle R., Griffiths, Gary L., Gottesman, Michael M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118110/
https://ncbi.nlm.nih.gov/pubmed/24930045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581702
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