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Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin
A major challenge in the treatment of cancer is multidrug resistance (MDR) that develops during chemotherapy. Here we demonstrate that tiopronin (1), a thiol-substituted N-propanoylglycine derivative, was selectively toxic to a series of cell lines expressing the drug efflux pump P-glycoprotein (P-g...
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| Main Authors: | , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208667/ https://ncbi.nlm.nih.gov/pubmed/21657271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2001663 |
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