Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity towards multidrug-resistant cells expressing P-glycoprotein()

Cancer multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters presents a significant unresolved clinical challenge. One strategy to resolve MDR is to develop compounds that selectively kill cells over-expressing the efflux transporter P-glycoprotein (MDR1, P-gp, ABCB1). We ha...

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Detalhes bibliográficos
Main Authors: Hall, Matthew D., Brimacombe, Kyle R., Varonka, Matthew S., Pluchino, Kristen M., Monda, Julie K., Li, Jiayang, Walsh, Martin J., Boxer, Matthew B., Warren, Timothy H., Fales, Henry M., Gottesman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201829/
https://ncbi.nlm.nih.gov/pubmed/21721528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2006047
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