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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase
Pyruvate kinase (PYK) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small molecule inhibitors. High-throughput screening has been used to...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3498827/ https://ncbi.nlm.nih.gov/pubmed/22906073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121014 |
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