The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site

Ehrlich's pioneering chemotherapeutic experiments published in 1904 (Ehrlich, P., and Shiga, K. (1904) Berlin Klin. Wochenschrift 20, 329–362) described the efficacy of a series of dye molecules including trypan blue and trypan red to eliminate trypanosome infections in mice. The molecular stru...

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Detalhes bibliográficos
Main Authors: Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Zhong, Wenhe, Michels, Paul A. M., Auld, Douglas S., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173065/
https://ncbi.nlm.nih.gov/pubmed/21733839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212613
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