Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein

Por Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Publicado no Biochem Pharmacol (2015)

Employing Information Theoretic Measures and Mutagenesis to Identify Residues Critical for Drug-Proton Antiport Function in Mdr1p of Candida albicans

Por Kapoor, Khyati, Rehan, Mohd, Lynn, Andrew M., Prasad, Rajendra
Publicado em 2010

Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp7...

Por Kapoor, Khyati, Bhatnagar, Jaya, Chufan, Eduardo E., Ambudkar, Suresh V.
Publicado em 2013

Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells

Por Shukla, Suneet, Schwartz, Candice, Kapoor, Khyati, Kouanda, Abdul, Ambudkar, Suresh V.
Publicado em 2012

Rational Mutational Analysis of a Multidrug MFS Transporter CaMdr1p of Candida albicans by Employing a Membrane Environment Based Computational Approach

Por Kapoor, Khyati, Rehan, Mohd, Kaushiki, Ajeeta, Pasrija, Ritu, Lynn, Andrew M., Prasad, Rajendra
Publicado em 2009

Conserved Walker A Cysteines 431 and 1074 in Human P-glycoprotein Are Accessible to Thiol-Specific Agents in the Apo and ADP-Vanadate Trapped Conformations

Por Sim, Hong-May, Bhatnagar, Jaya, Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Publicado em 2013

Revealing the fate of cell surface human P-glycoprotein (ABCB1): The Lysosomal Degradation Pathway

Por Katayama, Kazuhiro, Kapoor, Khyati, Ohnuma, Shinobu, Patel, Atish, Swaim, William, Ambudkar, Indu S., Ambudkar, Suresh V.
Publicado no Biochim Biophys Acta (2015)

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

Por Chufan, Eduardo E., Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T., Durell, Stewart R., Ambudkar, Suresh V.
Publicado em 2013

Design, synthesis and biological evaluation of (S)-valine thiazole-derived cyclic and non-cyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1)

Por Singh, Satyakam, Prasad, Nagarajan Rajendra, Kapoor, Khyati, Chufan, Eduardo E., Patel, Bhargav A., Ambudkar, Suresh V., Talele, Tanaji T.
Publicado em 2013

Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers

Por Fung, King Leung, Kapoor, Khyati, Pixley, Jessica N., Talbert, Darrell J., Kwit, Alexandra D.T., Ambudkar, Suresh V., Gottesman, Michael M.
Publicado no Drug Metab Dispos (2016)

Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL

Por Souza, Paloma S., Madigan, James P., Gillet, Jean-Pierre, Kapoor, Khyati, Ambudkar, Suresh V., Maia, Raquel C., Gottesman, Michael M., Fung, King Leung
Publicado no Exp Cell Res (2015)

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna(®)) with the human ABC drug transporter P-glycoprotein

Por Shukla, Suneet, Chufan, Eduardo E., Singh, Satyakam, Skoumbourdis, Amanda P., Kapoor, Khyati, Boxer, Matthew B., Duveau, Damien Y., Thomas, Craig J., Talele, Tanaji T., Ambudkar, Suresh V.
Publicado em 2014

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

Por Kapoor, Khyati, Finer-Moore, Janet S., Pedersen, Bjørn P., Caboni, Laura, Waight, Andrew, Hillig, Roman C., Bringmann, Peter, Heisler, Iring, Müller, Thomas, Siebeneicher, Holger, Stroud, Robert M.
Publicado no Proc Natl Acad Sci U S A (2016)

Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

Por Rawal, Manpreet Kaur, Khan, Mohammad Firoz, Kapoor, Khyati, Goyal, Neha, Sen, Sobhan, Saxena, Ajay Kumar, Lynn, Andrew M., Tyndall, Joel D. A., Monk, Brian C., Cannon, Richard D., Komath, Sneha Sudha, Prasad, Rajendra
Publicado em 2013