The complex of Arl2-GTP and PDEδ: from structure to function

por Hanzal-Bayer, Michael, Renault, Louis, Roversi, Pietro, Wittinghofer, Alfred, Hillig, Roman C.
Publicado 2002

Crystallization and molecular-replacement solution of a diagnostic fluorescent dye in complex with a specific Fab fragment

por Hillig, Roman C., Baesler, Siegfried, Urlinger, Stefanie, Stark, Yvonne, Bauer, Susanne, Badock, Volker, Huber, Martina, Bahr, Inke, Schirner, Michael, Licha, Kai
Publicado 2007

Identifying protein construct variants with increased crystallization propensity––A case study

por Malawski, Guido A., Hillig, Roman C., Monteclaro, Felipe, Eberspaecher, Uwe, Schmitz, Arndt A.P., Crusius, Kerstin, Huber, Martina, Egner, Ursula, Donner, Peter, Müller-Tiemann, Beate
Publicado 2006

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

por Kapoor, Khyati, Finer-Moore, Janet S., Pedersen, Bjørn P., Caboni, Laura, Waight, Andrew, Hillig, Roman C., Bringmann, Peter, Heisler, Iring, Müller, Thomas, Siebeneicher, Holger, Stroud, Robert M.
Publicado en Proc Natl Acad Sci U S A (2016)

Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

por Moosmayer, Dieter, Hilpmann, André, Hoffmann, Jutta, Schnirch, Lennart, Zimmermann, Katja, Badock, Volker, Furst, Laura, Eaton, John K., Viswanathan, Vasanthi S., Schreiber, Stuart L., Gradl, Stefan, Hillig, Roman C.
Publicado en Acta Crystallogr D Struct Biol (2021)

Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS(G12C)

por Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Publicado en ChemMedChem (2020)

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

por Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmann, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin
Publicado en Proc Natl Acad Sci U S A (2019)

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

por Eaton, John K, Furst, Laura, Ruberto, Richard A, Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J, Zimmermann, Katja, Cai, Luke L, Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C, Clemons, Paul A, Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E, Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L, Viswanathan, Vasanthi S, Schreiber, Stuart L
Publicado en Nat Chem Biol (2020)

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

por Eggert, Erik, Hillig, Roman C., Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D., ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E., Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V., Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J., Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H., Stellfeld, Timo, Stresemann, Carlo
Publicado en J Med Chem (2016)