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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
Since the late 1980s, mutations in the RAS genes have been recognized as major oncogenes with a high occurrence rate in human cancers. Such mutations reduce the ability of the small GTPase RAS to hydrolyze GTP, keeping this molecular switch in a constitutively active GTP-bound form that drives, unch...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377443/ https://ncbi.nlm.nih.gov/pubmed/30683722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812963116 |
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