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Sos-mediated cross activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

Mammalian cells contain three closely related ras genes, H-ras, K-ras and N-ras. Although, in a given tumor type, oncogenic mutations are selectively observed in only one of the ras genes, the acquisition of the transformed phenotype has been shown to require the contribution of the normal products...

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Bibliographic Details
Main Authors: Jeng, Hao-Hsuan, Taylor, Laura J., Bar-Sagi, Dafna
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640996/
https://ncbi.nlm.nih.gov/pubmed/23132018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2173
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