Wild-type H- and N-Ras promote mutant K-Ras driven tumorigenesis by modulating the DNA damage response

Mutations in KRAS are prevalent in human cancers and universally predictive of resistance to anti-cancer therapeutics. Although it is widely accepted that acquisition of an activating mutation endows RAS genes with functional autonomy, recent studies suggest that the wild-type forms of Ras may contr...

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Main Authors: Grabocka, Elda, Pylayeva-Gupta, Yuliya, Jones, Mathew JK, Lubkov, Veronica, Yemanaberhan, Eyoel, Taylor, Laura, Jeng, Hao Hsuan, Bar-Sagi, Dafna
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063560/
https://ncbi.nlm.nih.gov/pubmed/24525237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.005
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