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Wild-type H- and N-Ras promote mutant K-Ras driven tumorigenesis by modulating the DNA damage response
Mutations in KRAS are prevalent in human cancers and universally predictive of resistance to anti-cancer therapeutics. Although it is widely accepted that acquisition of an activating mutation endows RAS genes with functional autonomy, recent studies suggest that the wild-type forms of Ras may contr...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4063560/ https://ncbi.nlm.nih.gov/pubmed/24525237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.005 |
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