Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

The fungal ATP-binding cassette (ABC) transporter Cdr1 protein (Cdr1p), responsible for clinically significant drug resistance, is composed of two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs). We have probed the nature of the drug binding pocket by performing systematic mut...

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Detalhes bibliográficos
Main Authors: Rawal, Manpreet Kaur, Khan, Mohammad Firoz, Kapoor, Khyati, Goyal, Neha, Sen, Sobhan, Saxena, Ajay Kumar, Lynn, Andrew M., Tyndall, Joel D. A., Monk, Brian C., Cannon, Richard D., Komath, Sneha Sudha, Prasad, Rajendra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750147/
https://ncbi.nlm.nih.gov/pubmed/23824183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488353
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