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Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

The fungal ATP-binding cassette (ABC) transporter Cdr1 protein (Cdr1p), responsible for clinically significant drug resistance, is composed of two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs). We have probed the nature of the drug binding pocket by performing systematic mut...

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Autors principals: Rawal, Manpreet Kaur, Khan, Mohammad Firoz, Kapoor, Khyati, Goyal, Neha, Sen, Sobhan, Saxena, Ajay Kumar, Lynn, Andrew M., Tyndall, Joel D. A., Monk, Brian C., Cannon, Richard D., Komath, Sneha Sudha, Prasad, Rajendra
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750147/
https://ncbi.nlm.nih.gov/pubmed/23824183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488353
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