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Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

The fungal ATP-binding cassette (ABC) transporter Cdr1 protein (Cdr1p), responsible for clinically significant drug resistance, is composed of two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs). We have probed the nature of the drug binding pocket by performing systematic mut...

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Autori principali: Rawal, Manpreet Kaur, Khan, Mohammad Firoz, Kapoor, Khyati, Goyal, Neha, Sen, Sobhan, Saxena, Ajay Kumar, Lynn, Andrew M., Tyndall, Joel D. A., Monk, Brian C., Cannon, Richard D., Komath, Sneha Sudha, Prasad, Rajendra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750147/
https://ncbi.nlm.nih.gov/pubmed/23824183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488353
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