Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp70

P-glycoprotein (P-gp) is an ATP binding cassette transporter that effluxes a variety of structurally diverse compounds including anticancer drugs. Computational models of human P-gp in the apo- and nucleotide-bound conformation show that the adenine group of ATP forms hydrogen bonds with the conserv...

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Hlavní autoři: Kapoor, Khyati, Bhatnagar, Jaya, Chufan, Eduardo E., Ambudkar, Suresh V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820894/
https://ncbi.nlm.nih.gov/pubmed/24064216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498980
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