Revealing the fate of cell surface human P-glycoprotein (ABCB1): The Lysosomal Degradation Pathway

P-glycoprotein (P-gp) transports a variety of chemically dissimilar amphipathic compounds including anticancer drugs. Although mechanisms of P-gp drug transport are widely studied, the pathways involving its internalization are poorly understood. The present study is aimed at elucidating the pathway...

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Vydáno v:Biochim Biophys Acta
Hlavní autoři: Katayama, Kazuhiro, Kapoor, Khyati, Ohnuma, Shinobu, Patel, Atish, Swaim, William, Ambudkar, Indu S., Ambudkar, Suresh V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558211/
https://ncbi.nlm.nih.gov/pubmed/26057472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.06.001
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