Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein

gan Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Cyhoeddwyd yn Biochem Pharmacol (2015)

Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and...

gan Vahedi, Shahrooz, Chufan, Eduardo E., Ambudkar, Suresh V.
Cyhoeddwyd yn Biochem Pharmacol (2017)

Molecular Basis of the Polyspecificity of P-Glycoprotein (ABCB1): Recent Biochemical and Structural Studies

gan Chufan, Eduardo E., Sim, Hong-May, Ambudkar, Suresh V.
Cyhoeddwyd yn Adv Cancer Res (2015)

Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp7...

gan Kapoor, Khyati, Bhatnagar, Jaya, Chufan, Eduardo E., Ambudkar, Suresh V.
Cyhoeddwyd 2013

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

gan Shukla, Suneet, Abel, Biebele, Chufan, Eduardo E., Ambudkar, Suresh V.
Cyhoeddwyd yn J Biol Chem (2017)

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

gan Sajid, Andaleeb, Lusvarghi, Sabrina, Chufan, Eduardo E., Ambudkar, Suresh V.
Cyhoeddwyd yn PLoS One (2018)

Conserved Walker A Cysteines 431 and 1074 in Human P-glycoprotein Are Accessible to Thiol-Specific Agents in the Apo and ADP-Vanadate Trapped Conformations

gan Sim, Hong-May, Bhatnagar, Jaya, Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Cyhoeddwyd 2013

Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme

gan Chufán, Eduardo E., De, Mithu, Eipper, Betty A., Mains, Richard E., Amzel, L. Mario
Cyhoeddwyd 2009

Differential Reactivity Between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase (PHM)

gan Chufán, Eduardo E., Prigge, Sean T., Siebert, Xavier, Eipper, Betty A., Mains, Richard E., Amzel, L. Mario
Cyhoeddwyd 2010

How Much Binding Affinity Can be Gained by Filling a Cavity?

gan Kawasaki, Yuko, Chufan, Eduardo E., Lafont, Virginie, Hidaka, Koushi, Kiso, Yoshiaki, Amzel, L. Mario, Freire, Ernesto
Cyhoeddwyd 2009

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

gan Chufan, Eduardo E., Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T., Durell, Stewart R., Ambudkar, Suresh V.
Cyhoeddwyd 2013

Design, synthesis and biological evaluation of (S)-valine thiazole-derived cyclic and non-cyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1)

gan Singh, Satyakam, Prasad, Nagarajan Rajendra, Kapoor, Khyati, Chufan, Eduardo E., Patel, Bhargav A., Ambudkar, Suresh V., Talele, Tanaji T.
Cyhoeddwyd 2013

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein

gan Sajid, Andaleeb, Lusvarghi, Sabrina, Murakami, Megumi, Chufan, Eduardo E., Abel, Biebele, Gottesman, Michael M., Durell, Stewart R., Ambudkar, Suresh V.
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2020)

Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino...

gan Singh, Satyakam, Prasad, Nagarajan Rajendra, Chufan, Eduardo E., Patel, Bhargav A., Wang, Yi-Jun, Chen, Zhe-Sheng, Ambudkar, Suresh V., Talele, Tanaji T.
Cyhoeddwyd 2014

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna(®)) with the human ABC drug transporter P-glycoprotein

gan Shukla, Suneet, Chufan, Eduardo E., Singh, Satyakam, Skoumbourdis, Amanda P., Kapoor, Khyati, Boxer, Matthew B., Duveau, Damien Y., Thomas, Craig J., Talele, Tanaji T., Ambudkar, Suresh V.
Cyhoeddwyd 2014

Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2

gan Murakami, Megumi, Ohnuma, Shinobu, Fukuda, Michihiro, Chufan, Eduardo E., Kudoh, Katsuyoshi, Kanehara, Keigo, Sugisawa, Norihiko, Ishida, Masaharu, Naitoh, Takeshi, Shibata, Hiroyuki, Iwabuchi, Yoshiharu, Ambudkar, Suresh V., Unno, Michiaki
Cyhoeddwyd yn Drug Metab Dispos (2017)

Heme-Copper/Dioxygen Complexes: Towards Understanding Ligand-Environmental Effects on Coordination Geometry, Electronic Structure and Reactivity

gan Halime, Zakaria, Kieber-Emmons, Matthew T., Qayyum, Munzarin F., Mondal, Biplab, Puiu, Simona C., Chufán, Eduardo E., Sarjeant, Amy A. N., Hodgson, Keith O., Hedman, Britt, Solomon, Edward I., Karlin, Kenneth D.
Cyhoeddwyd 2010

Human-Mouse Chimeras With Normal Expression and Function Reveal That Major Domain Swapping is Tolerated by P-glycoprotein (ABCB1)

gan Pluchino, Kristen M., Hall, Matthew D., Moen, Janna K., Chufan, Eduardo E., Fetsch, Patricia A., Shukla, Suneet, Gill, Deborah R., Hyde, Stephen C., Xia, Di, Ambudkar, Suresh V., Gottesman, Michael M.
Cyhoeddwyd yn Biochemistry (2016)